Answer: The wrath of God is coming because of the "earthly nature," (verse 5).
MORE INFORMATION AND/OR OTHER SCRIPTURE REFERENCES:
The "earthly nature" is also called the "sinful nature" and "the flesh." God's wrath is coming against sin, and against those who live in sin. The "earthly nature" includes: sexual immorality, impurity, lust, evil desires and greed (which is idolatry), anger, rage, malice, slander, filthy language, and lying, (verses 5, 8 and 9).
Galatians 5:24: "Those who belong to Christ Jesus have crucified the sinful nature with its passions and desires."
Romans 1:18: "The wrath of God is being revealed from heaven against all the godlessness and wickedness of men who suppress the Truth by their wickedness..."